產(chǎn)品詳情介紹
白介素-21（interleukin-21，IL-21），屬于I類細(xì)胞因子，與IL-2、IL-4、IL-15等有較高的同源性，它與IL-7，IL-9共用γ c受體亞單位[1-2]。IL-21由活化的CD4+T細(xì)胞分泌，分子結(jié)構(gòu)與IL-15相似，參與調(diào)節(jié)B細(xì)胞增殖，協(xié)同IL-15促進(jìn)骨髓前體細(xì)胞增殖和NK細(xì)胞增殖、分化和細(xì)胞毒活性[3-5]。
[1] Ma SW, Huang X, Li YY, et al. High serum IL-21 levels after 12 weeks of antiviral therapy predict HBeAg seroconversion in chronic hepatitis B. J Hepatol. 2012 Apr;56(4):775-81.
[2] Li J, Ren W, Ma W, Zhang J, Shi J, Qin C. Interleukin-21 responses in patients with chronic hepatitis B. J Interferon Cytokine Res. 2015 Feb;35(2):134-42.
[3] Shi Y, Chen Z, Zhao Z, Yu Y, Fan H, Xu X, Bu X, Gu J. IL-21 Induces an Imbalance of Th17/Treg Cells in Moderate-to-Severe Plaque Psoriasis Patients. Front Immunol. 2019 Aug 7;10:1865.
[4] Nalbant A. IL-17, IL-21, and IL-22 Cytokines of T Helper 17 Cells in Cancer. J Interferon Cytokine Res. 2019 Jan;39(1):56-60.
[5] Sun S, Chen H, Zheng X, Ma C, Yue R. Analysis on the level of IL-6, IL-21, AMH in patients with auto-immunity premature ovarian failure and study of correlation. Exp Ther Med. 2018 Oct;16(4):3395-3398.
