產(chǎn)品詳情介紹
干擾素-γ （Interferon-gamma，IFN-γ），也稱為II型干擾素，是一種由自然殺傷細(xì)胞、活化的T細(xì)胞和某些其他免疫細(xì)胞產(chǎn)生的多功能細(xì)胞因子。IFN-γ在調(diào)節(jié)免疫反應(yīng)、細(xì)胞生長(zhǎng)、凋亡以及抗病毒和抗腫瘤活性中發(fā)揮著關(guān)鍵作用[1-2]。IFN-γ通過與其受體結(jié)合，激活特定的信號(hào)傳導(dǎo)途徑，可以增強(qiáng)免疫細(xì)胞的活性，包括巨噬細(xì)胞的活化和T細(xì)胞的增殖[3]。IFN-γ還能夠增強(qiáng)細(xì)胞的抗病毒狀態(tài)，抑制腫瘤細(xì)胞的生長(zhǎng)，并通過促進(jìn)CD95/Fas介導(dǎo)的凋亡過程來增強(qiáng)對(duì)腫瘤細(xì)胞的攻擊[4-5]。
[1] Chen SN, Huang B, Zhang XW, Li Y, Zhao LJ, Li N, Gao Q, Nie P. IFN-γ and its receptors in a reptile reveal the evolutionary conservation of type II IFNs in vertebrates. Dev Comp Immunol. 2013, 41(4):587-596.
[2] Mikulecky P, Cerny J, Biedermannová L, Petroková H, Kucha? M, Vondrá?ek J, Maly P, ?ebo P, Schneider B. Increasing affinity of interferon-γ receptor 1 to interferon-γ by computer-aided design. Biomed Res Int. 2013.
[3] Chang YP, Chen CL, Chen SO, Lin YS, Tsai CC, Huang WC, Wang CY, Hsieh CY, Choi PC, Lin CF. Autophagy facilitates an IFN-γ response and signal transduction. Microbes Infect. 2011, 13(11):888-894.
[4] Giammarioli AM, Vona R, Gambardella L, Ascione B, Maselli A, Barbati C, Tinari A, Malorni W. Interferon-gamma bolsters CD95/Fas-mediated apoptosis of astroglioma cells. FEBS J. 2009, 276(20):5920-5935.
[5] Hu X, Ivashkiv LB. Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity. 2009, 31(4):539-550.
