產品詳情介紹
Activin A由兩個抑制素β亞基通過二硫鍵連接組成同型二聚體，通過特定的受體激活細胞內的信號傳導途徑。Activin A在調控細胞的生長、分化、凋亡以及組織修復等多種生物學過程中起著關鍵作用[1]。Activin A通過與I型和II型激活素受體結合，激活SMAD依賴性信號通路，從而調節(jié)目標基因的表達。這一過程對于多種細胞功能和發(fā)育過程至關重要[2-3]。Activin A參與了多種疾病的發(fā)病機制，包括某些癌癥的發(fā)展、自身免疫性疾病的病理過程以及組織纖維等。Activin A的調節(jié)作用使其成為治療策略中的潛在靶點，尤其是在促進傷口愈合、改善免疫功能以及抗癌治療中 [4-6]。
[1] Massague J, Blain SW, Lo RS. TGFβ signaling in growth control, cancer, and heritable disorders. Cell. 2000 Apr 21;103(4):295-309.
[2] Chen Y G, Wang Q, Lin S L, et al. Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis. Experimental biology and medicine, 2006, 231(5): 534-544.
[3] Harrison C A, Gray P C, Vale W W, et al. Antagonists of activin signaling: mechanisms and potential biological applications. Trends in Endocrinology & Metabolism, 2005, 16(2): 73-78.
[4] Ghorbani-Dalini S, Azarpira N, Sangtarash M H, et al. Optimization of activin-A: a breakthrough in differentiation of human induced pluripotent stem cell into definitive endoderm. 3 Biotech, 2020, 10(5): 215.
[5] Mennen R H, Oldenburger M M, Piersma A H. Endoderm and mesoderm derivatives in embryonic stem cell differentiation and their use in developmental toxicity testing. Reproductive Toxicology, 2022, 107: 44-59.
[6] Ries A, Schelch K, Falch D, et al. Activin A: an emerging target for improving cancer treatment?. Expert Opinion on Therapeutic Targets, 2020, 24(10): 985-996.
